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Stress often causes bacteria to form biofilms. Stress can manifest as a physical barrier, ultraviolet light, or a toxic substance such as antibiotics. The formation of these biofilms takes from several hours to days, and they can be of different shapes, sizes, colors, and textures depending on the type of bacteria. Being in a biofilm state protects them from harmful substances in the environment - biofilms have a unique outer wall with different physical and chemical properties than their individual cells. They can coordinate metabolism, slow down their growth, and even form an impenetrable barrier of wrinkles and creases. This is one of the ways they achieve high antibiotic resistance. Researchers from the United Kingdom recently studied the transition of the Hay Bacillus bacterium from a free-moving swarm to a biofilm as a defense mechanism and published what they did to combat its antibiotic-resistant properties in eLife.
To determine if their test strain was behaving like the others, they first ran stress tests on them. They tested the bacteria's response to the physical barrier, ultraviolet light, and antibiotics. The addition of a physical barrier led to the transition of bacteria from one layer to a multilayer layer, followed by an increase in cell density and the formation of multilayer islands near the barrier. Later, wrinkles formed on the islands near the barrier in the place where they began to appear initially.
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When they applied ultraviolet light to the swarm, they again observed a drop in cell speed and an increase in density. And after the scientists added a large dose of the antibiotic kanamycin, the bacterial cells formed a biofilm. The researchers then developed a strategy to combat this bacterial biofilm. They added kanamycin to the environment of a new batch of swarming bacterial cells and watched as the biofilm began to form. They then re-injected the antibiotic at a much higher dose than the first, just before the biofilm formation was complete. As a result, the partially formed biofilm was destroyed and bacterial cells died. This shows that antibiotic-resistant bacteria lose their resistance to antibiotics when they undergo a phase transition, right before going into the biofilm, where they will become much more resistant. Thus, with the correct administration of antibiotics, the bacteria can be attacked in their most vulnerable state and destroyed. The researchers believe that similar transitions from swarm to biofilm occur in other bacterial species. Their research may pave the way for finding more effective ways to control clinically relevant bacteria. For example, Salmonella enterica, which spreads into the bloodstream and is transmitted through contaminated food. Or Pseudomonas aeruginosa with multiple drug resistance, which after surgery causes infections in the blood, lungs (pneumonia) and other parts of the body and spreads in hospitals.
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Like any other ability, memory can be trained and developed. The main thing is to choose the right exercise program.
Remembering the name of an actor or finding the keys left in the evening can sometimes be difficult. It takes a lot of effort to recover the information you need. Forgetting is a natural process that is designed to unload the nervous system from unclaimed information, to protect it from overstrain. But increased forgetfulness can significantly complicate life. It can be caused by lack of sleep, stress, addictions, or information overload.
If this problem is not related to injury or illness, it is realistic to solve it on your own. Memory can be developed and improved like any other ability. To activate its potential, regular exercise is necessary, as in sports or music. And vice versa - in their absence, the ability of the brain to memorize will decrease. Let's talk about the most effective ways to help strengthen memory and improve brain function.
1. Create associations and visualizations
It will be easier to remember new things if you connect the unknown with the already existing knowledge. The essence of the method of associations is to combine the known and the unknown into a single history, to mark new information with familiar markers. So the information received can be easily remembered and quickly reproduced at the right time. With the help of associative parallels, it is easy to learn road signs, passwords and dates, phone numbers and credit cards.
In 1980, the Olympic Games opened in Moscow, and 600 years before that, the Battle of Kulikovo took place. The number 5813 can be represented as a numerical expression 5 + 8 = 13. In this case, images are remembered even more efficiently. Better if they are unusual and even absurd. For example, the figure eight resembles a woman with large hips and voluminous breasts, and the figure five is a circus unicycle. In your mind, draw a fat lady who buys such a bike and rides it around the city.
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Such illustrations should be large, three-dimensional, color and as detailed as possible. The skill of coding into visual images is trained and quickly automated. In the future, it will not be difficult to restore in memory both these images, and the meaning that is embedded in them. Once again putting the keys in this or that place, imagine a flower blooming here. In the morning you will definitely not forget where exactly the flower grew in your house, and you will quickly find the right thing.
2. Learn poetry and read aloud
The time-tested method is memorizing poems. This is not about mindless cramming, but about understanding the meaning, its conscious perception. Make it a rule to teach one little piece every week. Gradually increase the volume of the material. It will be easier to remember if you break it down into several parts in advance and teach it in quatrains. You can do this anywhere: at lunch, while walking or in transport. Don't be afraid of a lot of repetitions. Over time, you will notice that it takes less and less time to memorize.
The effect will be even better if you take the works of those authors whose collections do not interest you. It will take more energy to learn such verses. Try to delve deeply into their content and reflect on the artistic techniques that the author used. Poetry can be recited in front of a mirror or recorded from memory. Reading aloud is equally useful. It helps to improve diction, intonation and develops auditory memory. If you don't like poetry, learn the lyrics.
3. Try to remember forgotten
It is not necessary to take the shopping list prepared before going to the store. On the one hand, such a list will help not to miss anything and at the same time not to buy too much. On the other hand, its absence will have a positive effect on the state of memory. Do not buy something this time - by the next trip you will have an incentive to better memorize items from the list and keep them in mind. Forgot someone's name, phone number, password or recipe ingredients? Try to remember. Take the time and take a few minutes to do this instead of looking for an answer in your smartphone or notebook. This is great for strengthening memory.
4. Master foreign languages
You can learn poems and songs not only in your native language. Don't know a foreign language - start mastering it. It is one of the best ways to activate brain cells and enhance memory capacity. If you memorize a few words every day, then after a couple of months you can feel a noticeable result. Learning a new language develops the ability to structure, analyze and memorize information. In addition, it is a good prevention of age-related diseases. For example, Alzheimer's disease. The most popular way to memorize foreign vocabulary is cards with words and expressions. This technique is based precisely on visual associations.
5. Remember the events of the day
Another way to activate memory is to plunge into the past day and remember all its events. Before going to bed, try to reconstruct snippets of dialogue, images of people, their facial expressions and gestures, every phone call and meals that made up your diet. Try to recreate the sequence of all actions from the moment of awakening. Provide these pictures in as much detail as possible. At the same time, it is important to connect imagination, visual, auditory and olfactory memory.
If it’s boring to remember the day in the form of imaginary illustrations, keep a diary and regularly write events on paper. It is recommended to repeat the same with the films watched. After the next movie show, scroll through the plot in your head again. Remember not only the main moments, but also the dialogues of the characters, the details of their clothes, the interiors of the shooting locations. It is even more useful to retell the content of films, plays, read articles and books to your friends. This not only trains memory well, but also develops speech, enriches vocabulary.
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